RETRACTED ARTICLE: Catalytic Au/PEDOT/Pt micromotors for cancer biomarker detection and potential breast cancer treatment
نویسندگان
چکیده
The synthesis and biomedical applications of nano/micromotors have attracted great attention. In this work, preparation characterization catalytic gold/poly(3,4-ethylenedioxythiophene)/platinum (Au/PEDOT/Pt) micromotors were reported to present their contribution for cancer biomarker miRNA-21 detection. Potential use these motors possible treatment was also illustrated after biocompability had shown. At first, anti-miRNA probe immobilized Au/PEDOT/Pt (probe DNA/Au/PEDOT/Pt/MMs) used the sensitive selective recognition synthetic target sequence proof-of-concept. Then intracellular studies carried out using four types cells (human breast cell line, MCF-7, human colorectal adenocarcinoma HT-29, lung carcinoma A-549 osteosarcoma SJSA-1). These high selectivity DNA/Au/PEDOT/Pt MCF-7 SJSA-1 cells. Later, antiproliferative cytotoxic effects potential investigated.
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ژورنال
عنوان ژورنال: Applied Nanoscience
سال: 2021
ISSN: ['2190-5517', '2190-5509']
DOI: https://doi.org/10.1007/s13204-021-01735-5